Genomics of Neurodegenerative Diseases and Aging (100-plus Study)

Department of Human Genetics, Amsterdam UMC.

Our research

An estimated 60-80% of the chance to develop Alzheimer’s disease depends on genetic factors, and similar percentages apply to other neurodegenerative diseases. Thousands of genetic risk factors are involved: some occur only very rarely in the population, others are more common. Each individual is uniquely vulnerable for developing diseases, which depends on the unique constellation of disease associated genetic variants they inherited from their parents. 

Therefore, it is important to know which genetic factors are involved: (1) they point towards the molecular processes underlying the disease, necessary to design accurate treatment strategies. (2) they can be used to predict the individual vulnerability for diseases, far before the onset of symptoms. In the future, when treatment options become available, predicting who is at risk before the onset of symptoms will allow timely and accurate treatment. 

Unfortunately, only a fraction of disease associated genetic elements is currently known. To identify novel genetic elements, our group compares the genetic constellations of those affected by neurodegenerative diseases with cognitively healthy individuals. Next to identifying risk-increasing genetic variants, our group takes a unique approach: we aim to identify genetic elements that protect against neurodegenerative diseases. 

We conceived the 100-plus Study: an on-going prospective cohort study of centenarians who self-reported to be cognitively healthy, their first-degree family members and their respective partners. By investigating the genetic constellations and biomaterials of those who escaped disease until extreme ages, we aim to learn how cognitive decline can be avoided. 

Ultimately we hope that our findings will contribute in helping others achieve the same: reaching extreme ages without dementia. Read more about the 100-plus Study.

In our aim to translate our scientific findings directly to the clinic, our research section forms the bridge between the department of Human Genetics and the Alzheimer Center Amsterdam.   

Dr. Henne Holstege, section leader & PI of the 100-plus Study, amidst several centenarians at the 100-plus day 2019. To read an interview with Dr. Henne Holstege click here.

The team

About our centenarians


Centenarians participated

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Age of oldest participant

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Lives independently


Mean age at inclusion


Brain donations


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24 - 27 Mai, 2023
ICC 2023

International Centenarian Consortium

Marstand, Zweden

A meeting where researchers from all over the world come together. The common denominator is that all researchers have a great interest in centenarians. 

16 - 20 July, 2023
Alzheimer's Association International Conference (AAIC)

The Alzheimer's Association International Conference is the world's largest forum for the dementia research community.


19 - 22 Septmeber, 2023
International Congress on Neurodegenerative Diseases - Malaga

The International Congress on Neurodegenerative Diseases will focus on research advances in neurodegenerative disorders. It will offer a forum to discuss a range of areas of interest related to basic, clinical and translational aspects of the research on neurodegenerative diseases, providing researchers from all over the world with opportunities to discuss and share experiences and entertain topics that stretch into the future and will be vital to procure the advancement into knowledge and treatment for these diseases.