Holstege Lab https://holstegelab.eu/ Wed, 15 Jul 2026 11:58:27 +0000 nl-NL hourly 1 https://wordpress.org/?v=6.8.6 https://holstegelab.eu/wp-content/uploads/2021/09/cropped-Logo_klein_transparant-32x32.png Holstege Lab https://holstegelab.eu/ 32 32 New milestone: KingFisher Apex for DNA, RNA, and protein extraction https://holstegelab.eu/new-milestone-kingfisher-apex-for-dna-rna-and-protein-extraction/?utm_source=rss&utm_medium=rss&utm_campaign=new-milestone-kingfisher-apex-for-dna-rna-and-protein-extraction https://holstegelab.eu/new-milestone-kingfisher-apex-for-dna-rna-and-protein-extraction/#respond Wed, 15 Jul 2026 11:58:26 +0000 https://holstegelab.eu/?p=5017 The Leuven team has reached an important milestone within the 100+ Study: the Thermo Fisher KingFisher Apex has been put into operation. The Thermo Fisher KingFisher Apex is a benchtop, high‑throughput instrument that automates magnetic bead–based purification of DNA, RNA, proteins and cells in research and clinical labs. It replaces manual, pipette‑heavy workflows with a […]

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]]> The Leuven team has reached an important milestone within the 100+ Study: the Thermo Fisher KingFisher Apex has been put into operation.

The Thermo Fisher KingFisher Apex is a benchtop, high‑throughput instrument that automates magnetic bead–based purification of DNA, RNA, proteins and cells in research and clinical labs. It replaces manual, pipette‑heavy workflows with a reproducible, “load plates and press start” process, reducing hands‑on time and operator‑to‑operator variability.

In the 100+ study it will mainly be used for DNA and RNA extractions from Human Brain samples.

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]]> https://holstegelab.eu/new-milestone-kingfisher-apex-for-dna-rna-and-protein-extraction/feed/ 0 Interview with dr. Sven van der Lee for AlzheimerNederland​ https://holstegelab.eu/sven-in-alzheimernederland/?utm_source=rss&utm_medium=rss&utm_campaign=sven-in-alzheimernederland https://holstegelab.eu/sven-in-alzheimernederland/#respond Wed, 08 Jul 2026 07:50:35 +0000 https://holstegelab.eu/?p=4962 Dr. Sven van der Lee is one of our senior researchers within the 100plus study and project leader at DemenTREE, the dementia biobank at the Alzheimer Center Amsterdam. He was recently interviewed by Alzheimer Nederland regarding his work on identifying genetic risk factors and protective genes associated with dementia. In this feature, he discusses his […]

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Dr. Sven van der Lee is one of our senior researchers within the 100plus study and project leader at DemenTREE, the dementia biobank at the Alzheimer Center Amsterdam. He was recently interviewed by Alzheimer Nederland regarding his work on identifying genetic risk factors and protective genes associated with dementia. In this feature, he discusses his research passion, professional ambitions, and his vision for how mapping the genetic architecture of dementia can unlock new therapeutic pathways.

Read the article on the Alzheimer Nederland website here (dutch).

Het bericht Interview with dr. Sven van der Lee for AlzheimerNederland​ verscheen eerst op Holstege Lab.

]]> https://holstegelab.eu/sven-in-alzheimernederland/feed/ 0 100+ retreat https://holstegelab.eu/100-retreat/?utm_source=rss&utm_medium=rss&utm_campaign=100-retreat https://holstegelab.eu/100-retreat/#respond Mon, 13 Apr 2026 13:37:51 +0000 https://holstegelab.eu/?p=4863 Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

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Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

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]]> https://holstegelab.eu/100-retreat/feed/ 0 Brain #100 for the CEN-Brain Age Continuum https://holstegelab.eu/brain-100-for-the-cen-brain-age-continuum/?utm_source=rss&utm_medium=rss&utm_campaign=brain-100-for-the-cen-brain-age-continuum https://holstegelab.eu/brain-100-for-the-cen-brain-age-continuum/#respond Tue, 31 Mar 2026 11:53:48 +0000 https://holstegelab.eu/?p=4832 Last week brain number 100 has been analyzed in Leuven for the CEN-Brain Age Continuum. An important milestone in our research into brain aging, which we are proud of.

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Last week brain number 100 has been analyzed in Leuven for the CEN-Brain Age Continuum. An important milestone in our research into brain aging, which we are proud of.

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]]> https://holstegelab.eu/brain-100-for-the-cen-brain-age-continuum/feed/ 0 TN2 Symposium 2026 https://holstegelab.eu/tn2-symposium-2026/?utm_source=rss&utm_medium=rss&utm_campaign=tn2-symposium-2026 https://holstegelab.eu/tn2-symposium-2026/#respond Fri, 27 Mar 2026 13:14:40 +0000 https://holstegelab.eu/?p=4809 On April 10th (09:05 – 09:40 AM), Henne Holstege will deliver a keynote at the TN2 Symposium on Pathways to Cognitive Resilience in Extreme Longevity. In this lecture, she will take us through her research on the factors that contribute to maintaining cognitive health at very old ages. TN2 brings together researchers from both basic […]

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On April 10th (09:05 – 09:40 AM), Henne Holstege will deliver a keynote at the TN2 Symposium on Pathways to Cognitive Resilience in Extreme Longevity. In this lecture, she will take us through her research on the factors that contribute to maintaining cognitive health at very old ages.

TN2 brings together researchers from both basic science and clinical practice within Translational Neuroscience, connecting experts from the Netherlands with international colleagues.

In addition to Henne Holstege’s lecture, Dr. Carlos Fitzsimmons and Dr. Evgenia Salta will also give presentations. They will speak, respectively, on the relationship between brain injury and neurodegenerative diseases, and on single-cell molecular mapping of human adult hippocampal neurogenesis in Alzheimer’s disease and resilience.

You can still register by clicking the link below and filling out the form to attend this presentation at the RDC-Adore building. Registration Form TN2 Symposium – April 10, 2026https://forms.office.com/pages/responsepage.aspx?id=GqvfaLsRxky-tSjXVphPtqNl8-YVR5tEmFpNxzb10g9UN0dWTUdFOFZKN0VKMVZLSThEVTFRVlBESS4u&route=shorturl

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]]> https://holstegelab.eu/tn2-symposium-2026/feed/ 0 ADPD 2026 – Copenhagen https://holstegelab.eu/adpd-2026-copenhagen/?utm_source=rss&utm_medium=rss&utm_campaign=adpd-2026-copenhagen https://holstegelab.eu/adpd-2026-copenhagen/#respond Mon, 16 Mar 2026 10:44:32 +0000 https://holstegelab.eu/?p=4737 Het bericht ADPD 2026 – Copenhagen verscheen eerst op Holstege Lab.

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AD/PD™ 2026 – Copenhagen

How do some people reach 100 years old with their cognition intact? Our researchers will share new insights at the AD/PD™ 2026 Conference in Copenhagen this week. 

Several members of our team will be presenting their latest research. If you’re attending the conference, we would love to connect! 

📍 Friday, 20 March 2026 – Hall A2 – 18:40

🧠 Symposium: Cognitively Healthy Centenarians: How Do They Do It?

 Presentations:

• Henne Holstege – Neuropathology in cognitively healthy centenarians: How did age affect their brain?

• Yaran Zhang – Peripheral epigenetic aging predicts survival independent of Alzheimer’s neuropathology and cognition in centenarians

• Marc Hulsman – Brains from cognitively healthy centenarians resisted accumulation of AD pathology and exhibit lower APOE, early proteasome response, and maintained β-oxidation

 Additional presentations:

 📍 Tuesday, 17 March 2026 – Hall A3 / Auditorium 10+11 – 08:30

🧬Daniel Alvarez Sirvent🧬– HLA-DRB115:01 associates with increased microglial activation in the aging brain, linking HLA genetic variation to Alzheimer’s neuropathology*

 📍 Wednesday, 18 March 2026 – Hall A3 / Auditorium 10+11 – 17:00

🧬Niccoló Tesi🧬– Structural variants shape genetic risk haplotypes in Alzheimer’s disease

 📍 Friday, 20 March 2026 – Auditorium 12 – 13:50

🧬Alex Salazar 🧬– Novel haplotypes in TMEM106B paradoxically modulate tau pathology

 Feel free to reach out if you’d like to meet during the conference.

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]]> https://holstegelab.eu/adpd-2026-copenhagen/feed/ 0 Lunch & Learn by Janna and Joan https://holstegelab.eu/lunch-learn-by-janna-and-joan/?utm_source=rss&utm_medium=rss&utm_campaign=lunch-learn-by-janna-and-joan https://holstegelab.eu/lunch-learn-by-janna-and-joan/#respond Mon, 15 Dec 2025 09:19:57 +0000 https://holstegelab.eu/?p=4530 During the Lunch & Learn session in October our colleagues Janna and Joan discussed the role of heredity in dementia. Through interactive statements and clear explanations, they addressed common questions and misconceptions. The session took place in the Colloquium in the Alzheimer Center Amsterdam. Heredity usually plays a role in dementia through genetic risk factors rather […]

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During the Lunch & Learn session in October our colleagues Janna and Joan discussed the role of heredity in dementia. Through interactive statements and clear explanations, they addressed common questions and misconceptions. The session took place in the Colloquium in the Alzheimer Center Amsterdam.

Heredity usually plays a role in dementia through genetic risk factors rather than a single genetic cause. A genetic predisposition can increase the risk of developing dementia, but it does not provide certainty. Lifestyle and environmental factors remain important and can influence risk, even in people with increased genetic susceptibility. Inherited forms of dementia that occur at a young age are rare.

The session also highlighted the DemenTREE research project, in which Alzheimer Center Amsterdam studies genetic and biological factors in young-onset dementia to improve diagnosis, risk prediction, and future treatment options.

The key takeaway: genes do not determine everything. Lifestyle continues to play a crucial role. We are looking forward to all the insights from this research.

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]]> https://holstegelab.eu/lunch-learn-by-janna-and-joan/feed/ 0 100-plus day 2025 https://holstegelab.eu/100-plus-day-2025/?utm_source=rss&utm_medium=rss&utm_campaign=100-plus-day-2025 https://holstegelab.eu/100-plus-day-2025/#respond Mon, 20 Oct 2025 11:03:33 +0000 https://holstegelab.eu/?p=4496 On the 3rd of October we had the pleasure of hosting the yearly 100-plus day at Van der Valk Almere. Sponsored by Aegon in support of Alzheimer’s research. Our special guests, the centenarians of the study, enjoyed a day full of joy! Lunch featured a delicious spread of Dutch favorites, followed by a performance from […]

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On the 3rd of October we had the pleasure of hosting the yearly 100-plus day at Van der Valk Almere. Sponsored by Aegon in support of Alzheimer’s research. Our special guests, the centenarians of the study, enjoyed a day full of joy!

Lunch featured a delicious spread of Dutch favorites, followed by a performance from Anne van Egmond. After the entertainment we had a drink and a bitterbal, during the “borreluurtje”. The day ended with catching up with peers. We had a wonderful day and looking forward to next years – 10th edition!

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]]> https://holstegelab.eu/100-plus-day-2025/feed/ 0 AD/PD 2025 https://holstegelab.eu/adpd-2025/?utm_source=rss&utm_medium=rss&utm_campaign=adpd-2025 https://holstegelab.eu/adpd-2025/#respond Wed, 09 Apr 2025 08:33:34 +0000 https://holstegelab.eu/?p=4352 from the 1st of April till the 5th of April 2025, AP/DP 2025 took place in Vienna. The AD/PD conference has become the main event of the year in the field of neurodegenerative diseases, attracting leading medical and scientific professionals from around the world.  Seven researchers from our group also joined the conference. With several […]

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from the 1st of April till the 5th of April 2025, AP/DP 2025 took place in Vienna. The AD/PD conference has become the main event of the year in the field of neurodegenerative diseases, attracting leading medical and scientific professionals from around the world.  Seven researchers from our group also joined the conference. With several talks, posters and a virtual oral we were well represented. 

Het bericht AD/PD 2025 verscheen eerst op Holstege Lab.

]]> https://holstegelab.eu/adpd-2025/feed/ 0 RDC ADORE https://holstegelab.eu/rdc-adore/?utm_source=rss&utm_medium=rss&utm_campaign=rdc-adore https://holstegelab.eu/rdc-adore/#respond Tue, 25 Feb 2025 09:13:53 +0000 https://holstegelab.eu/?p=4325 October 1, 2024 was a special day for Amsterdam UMC: after a construction period of about 2.5 years, the Research & Diagnostics Center ADORE was officially completed atthe VUmc location. In this research center, top scientists will soon work together on the development of new treatments against cancer and brain diseases, which is unique in […]

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October 1, 2024 was a special day for Amsterdam UMC: after a construction period of about 2.5 years, the Research & Diagnostics Center ADORE was officially completed at
the VUmc location. In this research center, top scientists will soon work together on the development of new treatments against cancer and brain diseases, which is unique in Europe. The diagnostic laboratories of Human Genetics and Pathology will also be housed here.

We are thrilled to move as well to this building. From the beginning of 2025 we are located at the fourth floor in the ADORE building.

With a total area of approximately 22,800 m², the Research & Diagnostics Center
ADORE houses state-of-the-art laboratories and office spaces. The building is connected to the Amsterdam UMC Imaging Center by a large glass atrium, making it easy for people to meet each other and share knowledge. From Van der Boechorststraat, the atrium is the main entrance for both the ADORE Research & Diagnostics Center and the Amsterdam UMC Imaging Center. Patients for the Amsterdam UMC Imaging Center can also enter via this entrance. The special, patchwork-like tiled floor in the atrium deserves an honorable mention.

From November until mid-2025, researchers from Amsterdam UMC will move into the new research building. The official opening of the Research & Diagnostics Center ADORE
is planned after the latest move.

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