We are very grateful for all the essential support, given by partners, sponsors, foundations and private donors.
VUmc Foundation sponsored several projects
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
N/A |
|
Start date: |
yearly |
Private donations to support our research come in via the VUmc.
100-plus Day
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
N/A |
|
Start date: |
yearly |
Aegon sponsors the yearly 100-plus Day.
Joint Programming Initiative Neurodegenerative Diseases
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
JPND2023-1822-087 |
|
Co-applicants: |
Alfredo Ramirez |
|
Start date: |
to be determined |
|
End date: |
to be determined |
BIRD-NL
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
|
|
Start date: |
01-12-2023 |
|
End date: |
31-12-2026 |
Spotlight on the neglected genome to escape dementia
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
09150172010083 |
|
Start date: |
01-12-2021 |
|
End date: |
30-11-2026 |
Comparison of long-read sequencing data of 200 AD patients and 200 centenarians.
AD-REPEAT
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
Health~Holland, |
|
Co-applicants: |
Prof. Marcel Reinders, TU Delft PacBio (Company) |
|
Start date: |
01-09-2021 |
|
End date: |
31-08-2025 |
The generation and comparison of PacBio long-read sequencing data from 150 early-onset AD patients from the Amsterdam Dementia Cohort, with 150 cognitively healthy centenarians from the 100-plus Study.
Blood-based markers for Alzheimer's pathology in cognitively healthy centenarians: revealing mechanisms of resistance and resilience
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
N/A |
|
Start date: |
01-06-2021 |
|
End date: |
01-06-2024 |
Using state-of-the-art proteomics techniques we will measure selected Alzheimer-associated biomarkers in the blood samples collected from centenarians and their family members.
Visit website.
ABOARD
| Project investigator: | Prof. Dr. W.M. van der Flier |
|---|---|
Project number: |
ZonMW (#73305095007 and |
|
Co-applicants: |
Dr. H. Holstege and Dr. S.J. van der Lee
|
|
Start date: |
01-04-2021 |
|
End date: |
31-03-2026 |
ABOARD (A personalized medicine approach for Alzheimer’s disease), is a collaboration of more than thirty partner who aim to prepare for a future in which Alzheimer’s disease is stopped before dementia has started. ABOARD achieves this by improving diagnostic markers, developing personalized risk scores and by focusing on prevention through increased awareness of dementia and brain health.
Visit website.
Hans und Ilse Breuer Stiftung Alzheimer Research Prize 2020
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
N/A (prize) |
|
Start date: |
01-03-2021 |
|
End date: |
28-02-2023 |
Click here to watch the nomination video.
100-plus SURFSara CONTINUATION
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
2020.030 |
|
Start date: |
01-11-2020 |
|
End date: |
18-11-2022 |
Access to the national computing facilities.
SORLA-FIX: Identifying and treating SORL1-associated Alzheimer's disease
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
JPND2019-466-197, |
|
Co-applicants: |
|
|
Start date: |
01-07-2020 |
|
End date: |
31-06-2023 |
Evaluation of the pathogenicity of variants in the SORL1 gene, and the identification of small molecules that selectively enhance SORLA activity.
Visit website.
Click here to read the project abstract.
100-plus ENABLING
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
N/A |
|
Start date: |
01-06-2020 |
|
End date: |
31-05-2024 |
Support for the brain autopsies and for sustaining the infrastructure of the 100-plus Study.
Repeat expansions in Alzheimer's Disease
| Project investigator: | Dr. Frank Jacobs |
|---|---|
Project number: |
Alzheimer Nederland WE.03-2018-07 |
|
Co-applicants: |
Dr. Henne Holstege |
|
Start date: |
01-11-2018 |
|
End date: |
31-10-2022 |
Investigation of genomic repeat expansions (VNTRs), and whether these explain disease association of AD-risk loci identified by GWAS.
100-plus SURFSara CONTINUATION
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
vuh17232 |
|
Start date: |
30-10-2018 |
|
End date: |
27-10-2020 |
Access to the national computing facilities.
100-plus Study: reaching extreme ages with maintained cognitive functions
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
N/A |
|
Start date: |
01-06-2018 |
|
End date: |
01-06-2020 |
(1) Expansion of the 100-plus Study with the inclusion of children and siblings of the centenarians and their respective partners. (2) Investigation off the centenarian peripheral immune system function, in collaboration with Leiden University Medical Center.
EXPAND
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
N/A |
|
Start date: |
01-01-2018 |
|
End date: |
31-12-2021 |
Identification of repeat expansions with different length-distributions between genomes from cognitively healthy centenarians and AD patients from the Amsterdam Dementia Cohort.
Understanding the role of the gut microbiome in pathogenesis
| Project investigator: | Prof. Dr. Cornelia van Duijn |
|---|---|
Project number: |
ZonMW 733050814 |
|
Co-applicants: |
Dr. Henne Holstege |
|
Start date: |
01-09-2017 |
|
End date: |
01-09-2022 |
Investigation of the key role of the gut microbiome in dementia through circulating immune and metabolic signals in large cohorts of Alheimer’s disease patients, Parkinsons disease patients and cognitively healthy individuals including centenarians.
100-plus SURFSara
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
vuh15318 |
|
Start date: |
04-11-2016 |
|
End date: |
27-11-2018 |
Access to the national computing facilities.
De-novo assembly of supercentenarian genome using PacBio sequencing data
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
vuh15226 |
|
Start date: |
09-02-2016 |
|
End date: |
31-12-2016 |
Access to the national computing facilities.
AD-Protectomics
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
IPB, Scientific Excellence program 2014 |
|
Start date: |
June 2015 |
|
End date: |
December 2016 |
Support for the comparison of the brain proteomes from the centenarians in the 100-plus Study with those from patients suffering from Alzheimer Disease (AD).
(Whole) Genome Sequencing 100-plus Study
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
WE.09-2014-03 |
|
Start date: |
01-09-2014 |
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End date: |
01-09-2018 |
Comparison of genomes from the centenarians in the 100-plus Study with those from patients suffering from Alzheimer Disease (AD), using next generation sequencing.
100-plus Study: old but not demented
| Project investigator: | Dr. Henne Holstege |
|---|---|
Project number: |
16020404 |
|
Start date: |
01-09-2014 |
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End date: |
01-09-2018 |
Comparison of the genomes and brain proteomes from the centenarians in the 100-plus Study with those from patients suffering from Alzheimer Disease (AD).